Lasing mode pattern of a quantum cascade photonic crystal surface-emitting microcavity laser

The identification of the lasing mode within a quantum cascade photonic crystal microcavity laser emitting at λ ~8 µm is presented. The symmetry of the lasing mode is determined by the position of nodal lines within micro-bolometer camera measurements of its polarized spatial distribution. Full three-dimensional finite-difference time-domain simulations are also performed, and the resulting vertically emitted radiation field pattern is seen to follow the experimental results closely

Quantum Cascade Surface-Emitting Photonic Crystal Laser

We combine photonic and electronic band structure engineering to create a surface-emitting quantum cascade microcavity laser. A high-index contrast two-dimensional photonic crystal is used to form a micro-resonator that simultaneously provides feedback for laser action and diffracts light vertically from the surface of the semiconductor surface. A top metallic contact allows electrical current injection and provides vertical optical confinement through a bound surface plasmon wave. The miniaturization and tailorable emission properties of this design are potentially important for sensing applications, while electrical pumping can allow new studies of photonic crystal and surface plasmon structures in nonlinear and near-field optics

Quantum cascade photonic-crystal microlasers

We describe the realization of Quantum Cascade photonic-crystal microlasers. Photonic and electronic bandstructure engineering are combined to create a novel Quantum Cascade microcavity laser source. A high-index contrast two-dimensional photonic crystal forms a micro-resonator that provides feedback for laser action and diffracts light vertically from the surface of the semiconductor chip. A top metallic contact is used to form both a conductive path for current injection as well as to provide vertical optical confinement to the active region through a bound surface plasmon state at the metal-semiconductor interface. The device is miniaturized compared to standard Quantum Cascade technology, and the emission properties can in principle be engineered by design of the photonic crystal lattice. The combination of size reduction, vertical emission, and lithographic tailorability of the emission properties enabled by the use of a high-index contrast photonic crystal resonant cavity makes possible a number of active sensing applications in the mid- and far-infrared. In addition, the use of electrical pumping in these devices opens up another dimension of control for fundamental studies of photonic crystal and surface plasmon structures in linear, non-linear, and near-field optics

Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial cancer cells

<p>Abstract</p> <p>Background</p> <p>Recent data provide significant evidence to support the hypothesis that there are sub-populations of cells within solid tumors that have an increased tumor initiating potential relative to the total tumor population. CD133, a cell surface marker expressed on primitive cells of neural, hematopoietic, endothelial and epithelial lineages has been identified as a marker for tumor initiating cells in solid tumors of the brain, colon, pancreas, ovary and endometrium. Our objectives were to assess the relative level of CD133 expressing cells in primary human endometrial tumors, confirm their tumorigenic potential, and determine whether CD133 expression was epigenetically modified.</p> <p>Methods</p> <p>We assessed CD133 expression in primary human endometrial tumors by flow cytometry and analyzed the relative tumorigenicity of CD133+ and CD133- cells in an <it>in vivo </it>NOD/SCID mouse model. We assessed potential changes in CD133 expression over the course of serial transplantation by immunofluorescence and flow cytometry. We further examined CD133 promoter methylation and expression in normal endometrium and malignant tumors.</p> <p>Results</p> <p>As determined by flow cytometric analysis, the percentage of CD133+ cells in primary human endometrial cancer samples ranged from 5.7% to 27.4%. In addition, we confirmed the tumor initiating potential of CD133+ and CD133^-cell fractions in NOD/SCID mice. Interestingly, the percentage of CD133+ cells in human endometrial tumor xenografts, as evidenced by immunofluorescence, increased with serial transplantation although this trend was not consistently detected by flow cytometry. We also determined that the relative levels of CD133 increased in endometrial cancer cell lines following treatment with 5-aza-2'-deoxycytidine suggesting a role for methylation in the regulation of CD133. To support this finding, we demonstrated that regions of the CD133 promoter were hypomethylated in malignant endometrial tissue relative to benign control endometrial tissue. Lastly, we determined that methylation of the CD133 promoter decreases over serial transplantation of an endometrial tumor xenograft.</p> <p>Conclusions</p> <p>These findings support the hypotheses that CD133 expression in endometrial cancer may be epigenetically regulated and that cell fractions enriched for CD133+ cells may well contribute to endometrial cancer tumorigenicity, pathology and recurrence.</p

Georgia Abortion Law and Our Commitment to Patients

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153775/1/art41143.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153775/2/art41143_am.pd

Quantum cascade photonic-crystal microlasers

We describe the realization of Quantum Cascade photonic-crystal microlasers. Photonic and electronic bandstructure engineering are combined to create a novel Quantum Cascade microcavity laser source. A high-index contrast two-dimensional photonic crystal forms a micro-resonator that provides feedback for laser action and diffracts light vertically from the surface of the semiconductor chip. A top metallic contact is used to form both a conductive path for current injection as well as to provide vertical optical confinement to the active region through a bound surface plasmon state at the metal-semiconductor interface. The device is miniaturized compared to standard Quantum Cascade technology, and the emission properties can in principle be engineered by design of the photonic crystal lattice. The combination of size reduction, vertical emission, and lithographic tailorability of the emission properties enabled by the use of a high-index contrast photonic crystal resonant cavity makes possible a number of active sensing applications in the mid- and far-infrared. In addition, the use of electrical pumping in these devices opens up another dimension of control for fundamental studies of photonic crystal and surface plasmon structures in linear, non-linear, and near-field optics

First Detection of Leishmania major DNA in Sergentomyia (Spelaeomyia) darlingi from Cutaneous Leishmaniasis Foci in Mali

Leishmania major complex is the main causative agent of zoonotic cutaneous leishmaniasis (ZCL) in the Old World. Phlebotomus papatasi and Phlebotomus duboscqi are recognized vectors of L. major complex in Northern and Southern Sahara, respectively. In Mali, ZCL due to L. major is an emerging public health problem, with several cases reported from different parts of the country. The main objective of the present study was to identify the vectors of Leishmania major in the Bandiagara area, in Mali. Methodology/Principal Findings: An entomological survey was carried out in the ZCL foci of Bandiagara area. Sandflies were collected using CDC miniature light traps and sticky papers. In the field, live female Phlebotomine sandflies were identified and examined for the presence of promastigotes. The remaining sandflies were identified morphologically and tested for Leishmania by PCR in the ITS2 gene. The source of blood meal of the engorged females was determined using the cyt-b sequence. Out of the 3,259 collected sandflies, 1,324 were identified morphologically, and consisted of 20 species, of which four belonged to the genus Phlebotomus and 16 to the genus Sergentomyia. Leishmania major DNA was detected by PCR in 7 of the 446 females (1.6%), specifically 2 out of 115 Phlebotomus duboscqi specimens, and 5 from 198 Sergentomyia darlingi specimens. Human DNA was detected in one blood-fed female S. darlingi positive for L. major DNA. Conclusion: Our data suggest the possible involvement of P. duboscqi and potentially S. darlingi in the transmission of ZCL in Mali